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1) The concept ‘genome sequence’.
a) What are the four main problems with the concept ‘the genome sequence’?
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e) How do you know if a genome sequence is correct?
Answers (Eckblom p1029-1030)
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2) What is a genome sequence and what is a reference genome sequence?
a) Explain the term reference genome.
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c) Explain the term ‘genetic or linkage map’.
Answers (Eckblom p1029)
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3) General terms for genome sequencing and genome assembly.
a) What is shotgun sequencing?
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f) What is de novo assembly?
Answers (Ekblom p1030, and internet)
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4) Assembly of a genome sequence.
a) What is the basis for connecting reads?
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Answers (Ekblom p1030-1031)
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5) Genome annotation.
a) Name three types of biologically relevant information that can be annotated to a genome.
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Answers (Ekblom p1036-1037, and internet)
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