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This simple formula indicates that it is easy to calculate the inbreeding coefficient of all animals in a population, as long as you know the additive genetic relationship between their parents. For example, the additive genetic relationship between a full brother and sister is 0.5. If they would be mated and have offspring, those offspring will be inbred. Their inbreeding coefficient would be ½ * 0.5 = 0.25. It means that for each locus the offspring will have a probability of 25% to be homozygous because its parents received the same alleles from their common ancestor. The more generations ago this common ancestor lived, the less the parents are related, so the lower the inbreeding coefficient.
Thus:
Important: An animal is inbred if, and only if, its parents are related! Fanimal = ½ * abetween parents |
INTERMEZZO: Why is Fanimal = ½ * abetween parents?
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This would be correct in haploid organisms. However, animals are diploid: they each have two alleles per locus. So parents have two chances of sharing an allele. Therefore, the probability that their offspring becomes homozygous, expressed as the inbreeding coefficient, becomes
Fanimal = 2 * abetween parents * ½ * ½ = ½ * abetween parents
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