4.15.3 Genomic selection (2024)

The fourth application of genetic markers is genomic selection. Genomic selection is a form of marker-assisted selection in which a very large number of genetic markers covering the whole genome is used. In this case all quantitative trait loci (QTL) are closely linked at the chromosomes with at least one marker. The large number of markers is obtained by chips using Single Nucleotide Polymorphisms (SNPs). Genomic selection is based on the analysis of 10000 up to 800000 SNPs. This high number of genetic markers is used as input in a genomic prediction formula that predicts the breeding value of an animal.

Figure1 genomic selection John-20161110-170828.jpg

(Source: Genomic management of animal genetic diversity, 2017. Editor: Kor Oldenbroek)

Definitions

Genomic selection is selection for a trait of interest with a very large number of genetic markers covering most QTL-loci related to the trait.

An SNP is a single nucleotide polymorphism caused by a mutation of a single nucleotide.

A complicating factor is recombination between SNPs and QTLs. This means that the value of animals in the reference population breaks down when the number of generations between them and the test population increases (more chance for recombination events). The best policy is to extend the reference population with DNA- and phenotypic data from new generations.