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In the strictest sense, phytochemicals are defined by plant scientists as chemicals produced by plants. However, confusingly the term is generally used by both human nutrition and plant science to describe chemicals from plants that may affect human health and well-being, but are not essential nutrients, e.g. caffeine. To prevent confusion a more appropriate term to point to this group of phytochemicals is the usage of “non-essential” or “non-nutrient” phytochemicals. As there are no known effects or symptoms as a consequence of their deficiency, also no target levels have been determined for intake2. It is recommended to daily consume five to eight portions (400–600 g) of fruits and vegetables, in order to reduce risk of cardiovascular disease, cancer, poor cognitive performance, and other diet-related diseases, as well as for the prevention of micronutrient deficiencies (WHO). Much of this potential of fruits and vegetables in disease prevention is thought to be provided by their complex mixture of phytochemicals, among which the preventive activity of antioxidants is most well documented (Rodriguez-Casado 2016; van Breda and de Kok 2018). Therefore, the use of supplements or fortification with only one phytochemical will probably not be effective to improve health. There is a consensus that whole fruit and vegetable intake is more important in providing health benefits than that of only one of their constituents, because of additive and synergistic effects (Rodriguez-Casado 2016). More than 200.000 phytochemicals have currently been identified (Chapter 3). An overview of several classes of phytochemicals is shown in Table 2.3.

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Table-2.3
Table-2.3

Category

Chemical class

Chemical subclass

Example

Plant-based food sources (examples)

Carbohydrates

Polysaccharides (dietary fiber)

Non-starch polysaccharides

Cellulose

Whole grains, almost all plants Pears, apples, citrus fruits

Pectins


Steroids

Phytosterols

Sterols

Campesterol

Whole grains, legumes, nuts, seeds, pulses, banana, apples, cruciferous vegetables, asparagus, onions







β-sitosterol




Stigmastrerol



Stanols


Organic acids

Short-chain organic acids

Aldonic acids

Ascorbic acid (vitamin C)

Pepper, kiwi, cruciferous vegetables, berries, citrus fruits,
tomato


Aldaric acids

Tartaric acid

Grapes, cranberries

Sulfur compounds

Thiosulfinates

Allicin

Garlic, leek, onion, chives



Diallyl sulfide


Nitrogen

containing

compounds

Amines

Benzylamines

Capsaicin

Chili peppers


Tryptamines

Psilocybin

Mushrooms

Cyanogenic glycosides


Amygdalin

Seeds of apricot, apple, peach and plum

Glucosinulates

Aliphatic glucosinulates

Sulforaphane

Broccoli, Brussels sprouts, cabbage, cauliflower













Sinigrin





Benzyl isothiocyanate

Allyl iosthiocyanate

Phenethyl isothiocyanate






Aromatic glucosinulates

Glucobrassicin

 Cabbage, broccoli, mustards, woad

Purines

Xanthines

Caffeine

Coffee bean

Other nitrogen

compounds

Indole alcohols

Indole-3 carbinol

Broccoli




Alkaloids

Pyridine alkaloids


Trigoneline

Potatoes, oats, peas, arabic coffee

Betalain alkaloids

Betacyanins

Betanin

Red beet



Betaxanthins

Indicaxanthin

Beets, red dragonfruit

Phenolics

Flavonoids

Anthocyanins

Cyanidin

Apple, berries, peach, red grape, carrot, red cabbage, red onion, red grapes
































Delphinidin

Malvidin

Flavanols

Catechin

Apple, berries, red-purple grape, apricot, peach, green bean





Epicatechin

Green tea

Proanthocyanidins

Green tea

Epicatechin gallate (ECG)



Epigallocatechin-3-gallate

Flavonols

Quercetin

Apple, apricot, berries, citrus fruits, cruciferous vegetables,



Kaempferol

onions, sweet potato, tomato, cherry

Myricitin


Flavones

Apigenin

Carrot, celery, parsley

Isoflavonoids

Genistein

Legumes, soy-bean, currants, alfalfa sprouts

Flavonones

Naringenin

Grapefruit, oranges, tomato

Dihydrochalcones

Phloretin

Apples, apricot


Phenolic acids

Hydroxybenzoic acids

Gallic acid

Blackberry, cherry, mango, red/purple grapes, pomegranate














Ellagic acid

Berries, pomegranate

Hydroxycinnamic acids

Ferulic acid

Apple, blackberry, blueberry, grapefruit, Brussels sprouts,




Chlorogenic acid

corn, tomato, cabbage, pepper

Caffeic acid



Para-Coumaric acid

Salicylates


Tomato, radish, pepper, broccoli, grapes, cherries, apples












Lignans




Pinoresinol

Banana, cranberry, orange, peach, broccoli, cabbage, carrot,



tomato, onion, potato, pumpkin

Coumarins

Coumarin

Tonka bean, vanilla grass, mullein, sweet woodruff






Coumestans

Coumestrol

Lima beans, alfalfa sprouts, soy beans

Furanocoumarins

Psoralen

Celery, parsley

Benzodioxoles

Apiole

Celery, parsley

Curcuminoids

Curcumin

Turmeric

Hydroxyphenyl-propenes

Eugenol

Basil, cinnamon, nutmeg

Stilbenoids





Resveratrol

Red grapes, berries, plums, peanuts



Pterostilbene

Blueberries

Piceatannol

Grapes

Terpenoids

Mono-terpenoids

Limonene

Grapefruit, lemon, orange, tangerine, carrot, celery

Triterpenoids

Phenolic terpenes

Vitamin E

Spinach, nuts, avocado



Saponins

Ursolic acid

Rosemary, basil

Phytosterols

Campesterol

Banana, pomegranate, pepper, grapefruit, onion

Tetrapenoids

Carotenoids

α- carotene

Carrot, pumpkin, sweet potato, tomato, apricot, mango,











β-carotene

cabbage, winter squash, cruciferous vegetables, spinach,

Lycopene

peach, red/pink grapefruit

Lutein




β-cryptoxanthin

Zeaxanthin

Table 2.3: Chemical classification of the main phytochemicals and their main plant based food (Table copied from: van Breda and de Kok 2018)


Informatie

References

Rodriguez-Casado A. 2016. The Health Potential of Fruits and Vegetables Phytochemicals: Notable Examples. Critical Reviews in Food Science and Nutrition 56: 1097–1107. DOI: 10.1080/10408398.2012.755149.

Van Breda SGJ, de Kok TMCM. 2018. Smart Combinations of Bioactive Compounds in Fruits and Vegetables May Guide New Strategies for Personalized Prevention of Chronic Diseases. Molecular Nutrition and Food Research 62: 1–12. DOI: 10.1002/mnfr.201700597.

World Health Organization. (n.d.). Home. Retrieved from https://www.who.int/

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